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Beginner Puzzle: Streptococcal Protein
Status: Closed


Name: Beginner Puzzle: Streptococcal Protein
Status: Closed
Created: 08/20/2012
Points: 100
Expired: 09/28/2012 - 23:00
Difficulty: Beginner
Description: The fold of this Streptococcal Protein is trapped in a local minimum. Although it looks good, it is incorrect. This is a short 57-residue protein for new players to try out after completing the Introductory Puzzles. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold.
Categories: Overall

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beta_helix's picture
User offline. Last seen 38 min 6 sec ago. Offline
Joined: 05/09/2008
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If you are new to Foldit, here are detailed instructions to get you started:

HINT: If you are having trouble with this puzzle, try using the "Align Guide" tool:

By right clicking on a region of the protein (not the guide) it will pull up a menu with 6 tools. The bottom right one is "Align Guide". Clicking on it will align the native guide to the region of the protein you selected.
This will help you see what sections on your protein correspond to the guide!

Working with the guide is much more user friendly when you use the advanced viewing options.
In the game click on Menu->General Options and select "Show Advanced GUI" and click Done.
Click on View, turn on 'Show Outline,' set the background color to white, and view stubs on the sidechains, view the guide, and set color relative to guide. Turn all the other view options off."

For even more info: http://foldit.wikia.com/wiki/Tlaloc%27s_Strategy#Technique_for_Matching_a_Guide

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons