puzzle picture
618: Bonus Impossibly Difficult CASP10 Puzzle
Status: Closed

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RankGroupScorePoints
1Anthropic Dreams22,37970
2Contenders22,16758
3Beta Folders21,96647
4foldeRNA21,94339
5Go Science21,82031
6Void Crushers21,70225
7L'Alliance Francophone21,54020
8Team Hungary21,52216
9FoldIt@Netherlands21,27612
10Brony@Home21,1979
11Russian team21,1877
12Newton's Cradle21,1646
13Gargleblasters20,6924
14Richard Dawkins Foundation20,4983
15Another Hour Another Point20,2602
16SETI.Germany20,0622
17BOINC@Poland19,7891
18Natural Abilities19,7171
19Freedom Folders19,6531
20Team Canada19,6431
21Geekdo19,1771
22Argentina18,9081
23DSN @ Home18,7101
24SETIKAH@KOREA18,6301
25Crunching Family18,4821


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beta_helix's picture
User offline. Last seen 17 hours 39 min ago. Offline
Joined: 05/09/2008
Groups: None
You thought CASP10 was over?

In CASP9 we had to skip these types of targets, because symmetry was not possible with Foldit... but that is no longer the case!

We wanted to give you the opportunity to fold TR699 in the context of a dimer, but we realize that this was already a big protein, and symmetry makes it even bigger.

This is why it is only worth 70 global points, think of it as an "extra credit" puzzle... it's just for fun so don't be too frustrated if it barely runs on your computer.

___Some possible hints___

I recommend turning off all sidechains, using Cartoon Thin, with Hydro Color and only showing Clashes. (If this is still too slow, you can try using "Line")

Since it forms a dimer, you probably want to look for a hydrophobic patch where the two sections come together. Coloring by Hydro can help you try to get as much orange at the interface.

If you have trouble loading this puzzle, try checking the box "disable network timeouts" when you login.

Please try to have fun with this one.
If it frustrates you, then at least be happy we didn't post it during CASP10!
___________________________________________________
This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=198

Note that the organizers gave us this hint:

"Starting model GDT_TS=85. Target should be treated as a dimer. "

GDT_TS=85 essentially means that ONLY 85% of the model superimposes correctly onto the native structure:
http://en.wikipedia.org/wiki/Global_distance_test

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valine at residue 44 is highly predicted to be part of a helix. However, the Valine at residue 56 is predicted to be in a sheet.

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