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616: Symmetric Beta Core Design Puzzle 2
Status: Closed

Summary

Name: 616: Symmetric Beta Core Design Puzzle 2
Status: Closed
Created: 08/10/2012
Points: 100
Expired: 08/18/2012 - 23:00
Difficulty: Intermediate
Description: This is part two of the small symmetric dimer design puzzle that uses a known structure as a starting point. We're interested to see what sort of designs you can come up with that respect the dimer symmetry, and fold around a central beta sheet. For the previous WXCXW puzzle we gave you an extended 20 residue chain at the C-terminus. We’ve moved that chain to the N terminus for this puzzle, which should allow for very different sorts of designs. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together!
Categories: Design, Overall, Symmetry

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1Void Crushers9,876100
2Anthropic Dreams9,87383
3Contenders9,81568
4Go Science9,77856
5Beta Folders9,76345

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jflat06's picture
User offline. Last seen 7 hours 14 min ago. Offline
Joined: 09/29/2010
Groups: Window Group
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For more information on this puzzle, please read the blog post at:

http://fold.it/portal/node/992627

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons