Joined: 05/09/2008
Groups: None
More info here:

Please look at the Notes for this puzzle (by pressing 3 in the Original Interface, or pressing 1 in the Selection Interface).


This is the page for this CASP10 refinement target:

The CASP10 organizers gave us this hint:

"The experimental NMR structure shows quite a bit of disorder in regions 91-93 and 142-163. Regions 6-20 and 51-64 need special attention. Starting model GDT_TS=69 (including the internal disordered regions)."

GDT_TS=69 essentially means that 69% of the model superimposes correctly onto the native structure:

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valine at residue 92 is highly predicted to be part of a sheet. However, the Valine at residue 92 is predicted to be in a helix.

Joined: 05/19/2009
Groups: Contenders
not visible in puzzle list

At the moment of writing, this puzzle is not visible in either main or devprev.

brow42's picture
User offline. Last seen 12 weeks 1 day ago. Offline
Joined: 09/19/2011
Groups: None
It's there now 8:00 PDT 15:00

It's there now 8:00 PDT 15:00 GMT.

Joined: 10/02/2011
"Disorder" is not clear to me

"Disorder" is not clear to me - does that mean those areas will not be scored for CASP so it doesn't matter if we move them?

Joined: 05/09/2008
Groups: None
They haven't been very clear on this.

Normally, disordered regions will not be scored.
See TR754 as an example:
"Residues 1-8 and 77-80 are disordered in the experimental structure and deleted from the model."

It probably means that they will simply ignore that region (but you never know... they have never mentioned this sort of thing in previous CASPs), I would just not worry about those regions and focus on Regions 6-20 and 51-64.

Sequence Logo can be found here (since it keeps vanishing):

Download links:
  Windows    OSX    Linux  
(10.12 or later)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Other Games: Mozak
Only search
Recommend Foldit
User login
Top New Users

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons