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Please look at the Notes for this puzzle (by pressing 3 in the Original Interface, or pressing 1 in the Selection Interface).

We recommend focusing your work on these 3 regions.


This is the page for this CASP10 refinement target:

The CASP10 organizers gave us this hint:

"Starting model GDT_TS=90. Special attention regions: 41-50, 100-110, 125-128."

GDT_TS=90 essentially means that 90% of the model superimposes correctly onto the native structure:

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 80-81, 94, 114-115, 123 & 134 are highly predicted to be part of a sheet. However, the Valines at residues 45, 52 & 103 are predicted to be in anything.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons