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610: CASP10 Refinement Puzzle: TR750
Status: Closed


Name: 610: CASP10 Refinement Puzzle: TR750
Status: Closed
Created: 08/01/2012
Points: 100
Expired: 08/11/2012 - 03:00
Difficulty: Intermediate
Description: This is the twentieth CASP10 Refinement Target. We've been told that ~77% of this model matches the native, so you'll need to refine ~23% of the structure! More info in the puzzle comments.
Categories: CASP10, Overall, Prediction

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beta_helix's picture
User offline. Last seen 52 min 33 sec ago. Offline
Joined: 05/09/2008
Groups: None
More info here:

Please note that the Cut Tool is available on all puzzles from now on!

This is the page for this CASP10 refinement target:

The CASP10 organizers gave us this hint:

"Starting model GDT_TS=77."

GDT_TS=77 essentially means that 77% of the model superimposes correctly onto the native structure:

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 84 & 176 are highly predicted to be part of a helix. However, the Valines at residues 64-65 & 99 are predicted to be part of a sheet.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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