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608: Symmetric CASP10 Refinement Puzzle: TR722
Status: Closed


1Void Crushers15,108100
3Beta Folders14,95762
6L'Alliance Francophone14,82528
7Anthropic Dreams14,79321
8Team Hungary14,78016
9Go Science14,71512
10Another Hour Another Point14,5978
11Russian team14,3196
13Natural Abilities14,2203
15Newton's Cradle14,1581
16Mojo Risin'14,1351
17Piratenpartei Deutschland14,0831
20Czech National Team13,8191
21Skeptics Guide to the Universe13,7011
24DSN @ Home13,5741
25Richard Dawkins Foundation13,5611

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beta_helix's picture
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More info here:

NOTE: The Cut Tool IS available for this symmetry puzzle, but only in the Developer Preview.
(If you want to try it out, please read "How do I try out the Foldit Developer Preview?" in the FAQ: http://fold.it/portal/info/faq )
Once the next update posts (early next week) the Cut Tool will be available in main.

This is the page for this CASP10 refinement target:

Note that the organizers gave us this hint:

"Starting model GDT_TS=58."

GDT_TS=58 essentially means that ONLY 58% of the model superimposes correctly onto the native structure:

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 23, 55, 85, 94, 112 & 115 are highly predicted to be part of a helix. However, the Valine at residue 34 is not predicted to be anything.

beta_helix's picture
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Possible Topologies

These were some of the possible templates for T0722:

This doesn't mean that TR722 folds up as a coiled-coil, but it might be a topology worth exploring.

We will try to post another Foldit Puzzle for TR722 where we give you just the starting model as a monomer (in case that it how the native folds up). It will likely be a very short puzzle.

beta_helix's picture
User offline. Last seen 10 hours 32 min ago. Offline
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Images gone!

As pointed out here (http://fold.it/portal/node/993286) the above images have disappeared!

They can be found here:
& below (just copy the entire link and paste it in your browser):
http://fold.it/portal/files/images/Screen shot 2012-07-28 at 2.03.54 PM.png
http://fold.it/portal/files/images/Screen shot 2012-07-28 at 2.04.17 PM.png
http://fold.it/portal/files/images/Screen shot 2012-07-28 at 2.04.55 PM_0.png

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