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608: Symmetric CASP10 Refinement Puzzle: TR722
Status: Closed


Name: 608: Symmetric CASP10 Refinement Puzzle: TR722
Status: Closed
Created: 07/28/2012
Points: 100
Expired: 08/06/2012 - 23:59
Difficulty: Intermediate
Description: This is the eighteenth CASP10 Refinement Target. This model was the best server prediction for target T0722, generated by the BAKER-ROSETTASERVER (using Rosetta@home). Despite being the prediction closest to the native, almost half of the model is incorrect: only ~58% of this model matches the solved structure. We believe that one possible reason is that this protein folds up as a dimer, so we are giving you the model with symmetry. Please read the puzzle comments for additional details.
Categories: CASP10, Overall, Prediction, Symmetry

Top Groups

1Void Crushers15,108100
3Beta Folders14,95762

Top Evolvers

1spdenne 38 Void Crushers15,104100
2utaca 111 Void Crushers15,05498
3Wildcat777 111 Void Crushers15,01795
4mimi 111 Contenders14,95892
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Top Soloists

1Wildcat777 111 Void Crushers15,108100
2marie_s 111  15,02098
3Hanto_FZ140E_4G 111  14,99395
4randomlil 111 Beta Folders14,95792
5doug.ehlert 111 Contenders14,92090

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beta_helix's picture
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Joined: 05/09/2008
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More info here:

NOTE: The Cut Tool IS available for this symmetry puzzle, but only in the Developer Preview.
(If you want to try it out, please read "How do I try out the Foldit Developer Preview?" in the FAQ: http://fold.it/portal/info/faq )
Once the next update posts (early next week) the Cut Tool will be available in main.

This is the page for this CASP10 refinement target:

Note that the organizers gave us this hint:

"Starting model GDT_TS=58."

GDT_TS=58 essentially means that ONLY 58% of the model superimposes correctly onto the native structure:

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 23, 55, 85, 94, 112 & 115 are highly predicted to be part of a helix. However, the Valine at residue 34 is not predicted to be anything.

beta_helix's picture
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Joined: 05/09/2008
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Possible Topologies

These were some of the possible templates for T0722:

This doesn't mean that TR722 folds up as a coiled-coil, but it might be a topology worth exploring.

We will try to post another Foldit Puzzle for TR722 where we give you just the starting model as a monomer (in case that it how the native folds up). It will likely be a very short puzzle.

beta_helix's picture
User offline. Last seen 1 hour 57 min ago. Offline
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Images gone!

As pointed out here (http://fold.it/portal/node/993286) the above images have disappeared!

They can be found here:
& below (just copy the entire link and paste it in your browser):
http://fold.it/portal/files/images/Screen shot 2012-07-28 at 2.03.54 PM.png
http://fold.it/portal/files/images/Screen shot 2012-07-28 at 2.04.17 PM.png
http://fold.it/portal/files/images/Screen shot 2012-07-28 at 2.04.55 PM_0.png

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