puzzle picture
625: Sepsis Puzzle
Status: Closed


Name: 625: Sepsis Puzzle
Status: Closed
Created: 07/24/2012
Points: 120
Expired: 09/07/2012 - 15:00
Difficulty: Intermediate
Description: Sugar molecules such as the one here are coated on the surface of many human pathogens. We are attempting to increase the protein-sugar binding interactions by extending a specific loop region of this protein. Please build upon this region, and extend it to make additional hydrogen bond interactions with the sugar. The best Foldit designs will then be used to generate potential pathogen capture reagents. Please read the blogpost for more info and if you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle.
Categories: Design, Overall

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beta_helix's picture
User offline. Last seen 9 hours 2 min ago. Offline
Joined: 05/09/2008
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If you are new to Foldit, here are detailed instructions to get you started:

This puzzle is worth 120 global points!

More details about this puzzle in the blog:

Susume's picture
User offline. Last seen 4 hours 17 min ago. Offline
Joined: 10/02/2011
Tip: To see the parts of the

Tip: To see the parts of the sugar that you can bond to, check Show bonds (non-protein) and Show bondable atoms in the View menu. Make sure Show bonds (loop) and Show bonds (sidechain) are also on. Blue can bond to red, and purple can bond to either blue or red.

marie_s's picture
User offline. Last seen 2 years 5 weeks ago. Offline
Joined: 05/18/2008
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see feedback

thx Susume and Seth

XBane's picture
User offline. Last seen 9 years 27 weeks ago. Offline
Joined: 09/02/2012
Groups: None
subscore discrepancy

current.GetSegmentEnergySubscore(M,"bonding") does not return the same value for the ligand as the Tab key.

Joined: 11/10/2007
Groups: Window Group
Thanks for reporting the

Thanks for reporting the score discrepancy in scripting. The tab key is reporting the correct number. That has been fixed and will be part of the next update.

Angus's picture
User offline. Last seen 4 weeks 4 days ago. Offline
Joined: 06/04/2008
Groups: Beta Folders
Is this puzzle closed, open

Is this puzzle closed, open or lost in-between? It's 2:13 past closing time but still shows "Active" and no points assigned.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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