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605: CASP10 Refinement Puzzle: TR710
Status: Closed

Summary

Name: 605: CASP10 Refinement Puzzle: TR710
Status: Closed
Created: 07/23/2012
Points: 100
Expired: 08/02/2012 - 23:59
Difficulty: Intermediate
Description: This is the fifteenth CASP10 Refinement Target. We've been told that about 75% of this model matches the native, so you'll need to refine ~25% of the structure! More info in the puzzle comments.
Categories: CASP10, Overall, Prediction

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Comments

beta_helix's picture
User offline. Last seen 1 day 18 hours ago. Offline
Joined: 05/09/2008
Groups: None
More info here:

Please note that the Cut Tool is available on this puzzle!

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=188

The CASP10 organizers gave us this hint:

"Starting model GDT_TS=75."

GDT_TS=75 essentially means that 75% of the model superimposes correctly onto the native structure:
http://en.wikipedia.org/wiki/Global_distance_test

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 19, 52, 85, 145 & 177 are highly predicted to be part of a helix. However, the Valines at residues 96 & 100 are not.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons