puzzle picture
596: CASP10 Target T0740
Status: Closed

Summary

Name: 596: CASP10 Target T0740
Status: Closed
Created: 07/11/2012
Points: 100
Expired: 07/21/2012 - 09:00
Difficulty: Advanced
Description: The fourteenth CASP10 target is another big one: 165 residues and none of the alignment programs were able to find good templates for this target. It might be the case that this protein has no homologs. We are giving you 4 different templates (in hope that one of them is correct) for now, and will provide you with some server predictions soon. More details about this CASP target are in the puzzle comments.
Categories: CASP10, Overall, Prediction

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RankGroupScorePoints
1Anthropic Dreams11,606100
2Void Crushers11,46680
3Go Science11,46263
4Contenders11,41950
5foldeRNA11,38839

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Comments

beta_helix's picture
User offline. Last seen 23 hours 30 min ago. Offline
Joined: 05/09/2008
Groups: None
Additional info about this CASP target

Here is the CASP link for this target (showing the amino acid sequence):
http://predictioncenter.org/casp10/target.cgi?id=165
____________________________________________________

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Leucines at residues 106 & 141 are highly predicted to be in a helix. However, the Leucine at residue 115 is predicted to be in a sheet.

NOTE THAT THIS SECONDARY STRUCTURE PREDICTION IS OBVIOUSLY NOT 100% correct, since it is impossible to have a protein with a single sheet.
Clearly there is either another strand or there are no sheets at all!
____________________________________________________

Link to template PDBs:

http://www.pdb.org/pdb/explore/explore.do?structureId=1aep
http://www.pdb.org/pdb/explore/explore.do?structureId=2eh3
http://www.pdb.org/pdb/explore/explore.do?structureId=2gyq
http://www.pdb.org/pdb/explore/explore.do?structureId=1yvi

Joined: 05/19/2009
Groups: Contenders
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tamirh's picture
User offline. Last seen 5 years 41 weeks ago. Offline
Joined: 05/11/2012
.

It's showing up for me in my devprev client. Is anyone else on devprev having this issue?

Have you tried restarting the client(s)? If your connection got temporarily lost it could have not downloaded the new list correctly.

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