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595: 30 Residue Symmetric Trimer Freestyle
Status: Closed

Summary

Name: 595: 30 Residue Symmetric Trimer Freestyle
Status: Closed
Created: 06/27/2012
Points: 100
Expired: 07/18/2012 - 08:00
Difficulty: Intermediate
Description: This is a small (30 residue) symmetric trimer design puzzle; there will be three symmetric chains to play with. We saw some very interesting structures for the related 20 residue puzzle (Puzzle 553), but ten extra residues, and three-fold symmetry, should make this a very different challenge. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together - and a symmetric trimer can be thought of as having three 2-fold interfaces. Stay tuned for higher-order symmetries, like tetrahedra and octahedra!
Categories: Design, Overall, Symmetry

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NOTE:

This puzzle's deadline was extended due to the particularly heavy load of CASP10 puzzles this week.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons