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586: Large CASP10 Refinement Puzzle: TR681
Status: Closed


Name: 586: Large CASP10 Refinement Puzzle: TR681
Status: Closed
Created: 06/25/2012
Points: 100
Expired: 07/05/2012 - 10:00
Difficulty: Intermediate
Description: The eighth CASP10 Refinement Target has 224 residues! This model was the best server prediction for target T0681, generated by the MULTICOM-CONSTRUCT server. We've been told that ~78% of this model matches the native, so you just need to find which 22% to refine! We are giving you a couple extra days to work on this one due to its size. More info in the puzzle comments.
Categories: CASP10, Overall, Prediction

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beta_helix's picture
User offline. Last seen 1 week 6 days ago. Offline
Joined: 05/09/2008
Groups: None
More info here:

This is the page for this CASP10 refinement target:

Note that the organizers gave us this hint:

"Starting model GDT_TS=78."

GDT_TS=78 essentially means that 78% of the model superimposes correctly onto the native structure:

We believe that MULTICOM-CONSTRUCT_TS3.pdb is identical to the refinement model.

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Leucines at residues 14-15 are highly predicted to be in a helix. However, the Leucines at residues 54 & 86 are predicted to be part of a sheet.

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