puzzle picture
586: Large CASP10 Refinement Puzzle: TR681
Status: Closed

Summary

Name: 586: Large CASP10 Refinement Puzzle: TR681
Status: Closed
Created: 06/25/2012
Points: 100
Expired: 07/05/2012 - 10:00
Difficulty: Intermediate
Description: The eighth CASP10 Refinement Target has 224 residues! This model was the best server prediction for target T0681, generated by the MULTICOM-CONSTRUCT server. We've been told that ~78% of this model matches the native, so you just need to find which 22% to refine! We are giving you a couple extra days to work on this one due to its size. More info in the puzzle comments.
Categories: CASP10, Overall, Prediction

Top Groups

RankGroupScorePoints
1Anthropic Dreams13,611100
2Void Crushers13,53580
3Go Science13,46063
4Beta Folders13,43350
5foldeRNA13,41439

Top Evolvers

Top Soloists



Need this puzzle? Log in to download.  

Comments

beta_helix's picture
User offline. Last seen 1 day 20 hours ago. Offline
Joined: 05/09/2008
Groups: None
More info here:

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=140

Note that the organizers gave us this hint:

"Starting model GDT_TS=78."

GDT_TS=78 essentially means that 78% of the model superimposes correctly onto the native structure:
http://en.wikipedia.org/wiki/Global_distance_test

We believe that MULTICOM-CONSTRUCT_TS3.pdb is identical to the refinement model.

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Leucines at residues 14-15 are highly predicted to be in a helix. However, the Leucines at residues 54 & 86 are predicted to be part of a sheet.

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons