|
586: Large CASP10 Refinement Puzzle: TR681
Status: Closed
|
Summary
| Name: | 586: Large CASP10 Refinement Puzzle: TR681 |
|---|---|
| Status: | Closed |
| Created: | 06/25/2012 |
| Points: | 100 |
| Expired: | 07/05/2012 - 10:00 |
| Difficulty: | Intermediate |
| Description: | The eighth CASP10 Refinement Target has 224 residues! This model was the best server prediction for target T0681, generated by the MULTICOM-CONSTRUCT server. We've been told that ~78% of this model matches the native, so you just need to find which 22% to refine! We are giving you a couple extra days to work on this one due to its size. More info in the puzzle comments. |
| Categories: | CASP10, Overall, Prediction |
Top Groups
Top Evolvers
Top Soloists
Need this puzzle? Log in to download.
This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=140
Note that the organizers gave us this hint:
"Starting model GDT_TS=78."
GDT_TS=78 essentially means that 78% of the model superimposes correctly onto the native structure:
http://en.wikipedia.org/wiki/Global_distance_test
We believe that MULTICOM-CONSTRUCT_TS3.pdb is identical to the refinement model.
Here is the sequence logo predicted by the SAM server:
H = helix
E = sheet
C = loop (or coil)
The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.
For example, the Leucines at residues 14-15 are highly predicted to be in a helix. However, the Leucines at residues 54 & 86 are predicted to be part of a sheet.