puzzle picture
584: Advanced CASP10 Refinement Puzzle: TR679
Status: Closed


Name: 584: Advanced CASP10 Refinement Puzzle: TR679
Status: Closed
Created: 06/24/2012
Points: 100
Expired: 07/05/2012 - 23:59
Difficulty: Advanced
Description: Not only is the eighth CASP10 Refinement Target 223 residues, but this best server prediction for target T0679 was generated by the RosettaServer (using Rosetta@home). Because of this, we are giving you the Rosetta model as a template using the Alignment Tool minus the regions the CASP assesors have told us are incorrect; start by threading it and fixing the cutpoints. This one will be tough, so we are giving you 10 days. More info in the puzzle comments.
Categories: CASP10, Overall, Prediction

Top Groups

1Go Science13,221100
2Anthropic Dreams13,13080
4Void Crushers13,04450

Top Evolvers

Top Soloists

Need this puzzle? Log in to download.  


beta_helix's picture
User offline. Last seen 2 weeks 5 days ago. Offline
Joined: 05/09/2008
Groups: None

The CASP organizers (who have seen the native solved structure of this protein) have told us:

"Regions showing significant deviation: 25-45, 146-156, 187-197."

These are the 3 regions that you'll need to work on, after you thread the Rosetta model using the Alignment Tool.

You'll probably want to freeze the rest of the protein while you initially refine these 3 regions.

beta_helix's picture
User offline. Last seen 2 weeks 5 days ago. Offline
Joined: 05/09/2008
Groups: None
More info here:

This is the page for this CASP10 refinement target:

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

You'll notice that the secondary structure predictions in the regions you need to work on (residues 25-45, 146-156 & 187-197) don't tell you very much!

marie_s's picture
User offline. Last seen 2 years 18 weeks ago. Offline
Joined: 05/18/2008
Groups: None
why so much conflicts ?

in the "good" parts?

brow42's picture
User offline. Last seen 3 weeks 2 days ago. Offline
Joined: 09/19/2011
Groups: None
it's an extended chain

the chain 25-45 runs right down the middle of the puzzle clashing with everything. Use the cut tool to move it outside.

User login
Download links:
  Windows    OSX    Linux  
(10.12 or later)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media

Only search fold.it
Other Games: Mozak
Recommend Foldit
Top New Users

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons