puzzle picture
583: Large CASP10 Refinement Puzzle: TR689
Status: Closed

Summary

Name: 583: Large CASP10 Refinement Puzzle: TR689
Status: Closed
Created: 06/24/2012
Points: 100
Expired: 07/03/2012 - 13:00
Difficulty: Intermediate
Description: The seventh CASP10 Refinement Target has 234 residues! This model was the best server prediction for target T0689, generated by the Jiang_Fold server. We've been told that ~87% of this model matches the native, so you just need to find which 13% to refine! We are giving you a couple extra days to work on this one due to its size. More info in the puzzle comments.
Categories: CASP10, Overall, Prediction

Top Groups

RankGroupScorePoints
1Anthropic Dreams14,390100
2Void Crushers14,36179
3Beta Folders14,35061
4Contenders14,33347
5Go Science14,33236

Top Evolvers

Top Soloists



Need this puzzle? Log in to download.  

Comments

beta_helix's picture
User offline. Last seen 1 day 13 hours ago. Offline
Joined: 05/09/2008
Groups: None
More info here:

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=132

Note that the organizers gave us this hint:

"Starting model GDT_TS=87."

GDT_TS=87 essentially means that 87% of the model superimposes correctly onto the native structure:
http://en.wikipedia.org/wiki/Global_distance_test

We believe that Jiang_Fold_TS1.pdb is identical to the refinement model.

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 34, 49, 54, 57, 66, 71 & 183 are highly predicted to be in sheets. However, the Valines at residues 3, 107, 137 & 144 are predicted to be anything.

spmm's picture
User offline. Last seen 19 weeks 6 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
6-7 minutes to run fuse

Just a note - on an ok machine (i7-720QM) with 8GB RAM, foldit and a browser running it is taking 6-7 minutes to run Blue Fuse.

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons