571: Tissue Regeneration Design Puzzle

Summary

Name:

Status:

Closed

Created:

06/06/2012

Points:

100

Expired:

06/15/2012 - 15:00

Difficulty:

Beginner

Description:

We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. Read the new blogpost for more details.

Categories:

Design, Overall

Rank

Group

Score

Points

Go Science

9,570

100

9,569

9,559

9,545

9,544

Rank

Player

Group

Score

Points

smilingone 127 7154

Go Science

9,570

100

Hanto_FZ140E_4G 127 7154

9,569

9,568

9,568

9,563

Rank

Player

Group

Score

Points

BitSpawn 127 7154

Anthropic Dreams

9,569

100

9,564

9,560

9,559

9,556

Thu, 06/07/2012 - 16:57

mottiger 127 1143

Offline

Joined: 08/30/2011

Groups: Anthropic Dreams

open/unreleased

puzzle is open on the design overview page but the status is unreleased.
are you working on it right now to bring it up?

Fri, 06/08/2012 - 02:29

beta_helix 127 7154

Offline

Joined: 05/09/2008

Groups: None

Yes, unreleased means it'll be up soon :-)

We're just making sure it's working properly and the descriptions are helpful.

Sat, 06/09/2012 - 01:16

BootsMcGraw 127 3596

Offline

Joined: 12/06/2008

Groups: Contenders

Scoring artifacts

I'm not sure if any of the other top scorers on this puzzle are seeing this, but I am finding that saturating this helix with aromatics is producing the highest scores.

I doubt highly that a real-life helix could contain so many tryptophans, tyrosines, and phenylalanines, yet remain a stable structure.

We've seen this scoring bug, before.