puzzle picture
571: Tissue Regeneration Design Puzzle
Status: Closed

Summary

Name: 571: Tissue Regeneration Design Puzzle
Status: Closed
Created: 06/07/2012
Points: 100
Expired: 06/15/2012 - 15:00
Difficulty: Beginner
Description: We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. Read the new blogpost for more details.
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Go Science9,570100
2Anthropic Dreams9,56979
3Contenders9,55961
4foldeRNA9,54547
5Team Hungary9,54436

Top Evolvers

Top Soloists



Need this puzzle? Log in to download.  

Comments

Joined: 08/30/2011
open/unreleased

puzzle is open on the design overview page but the status is unreleased.
are you working on it right now to bring it up?

beta_helix's picture
User offline. Last seen 1 day 44 min ago. Offline
Joined: 05/09/2008
Groups: None
Yes, unreleased means it'll be up soon :-)

We're just making sure it's working properly and the descriptions are helpful.

Joined: 12/06/2008
Groups: Contenders
Scoring artifacts

I'm not sure if any of the other top scorers on this puzzle are seeing this, but I am finding that saturating this helix with aromatics is producing the highest scores.

I doubt highly that a real-life helix could contain so many tryptophans, tyrosines, and phenylalanines, yet remain a stable structure.

We've seen this scoring bug, before.

marie_s's picture
User offline. Last seen 1 year 42 weeks ago. Offline
Joined: 05/18/2008
Groups: None
I aggree

I cannot get rid of 3 tryptophans

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons