puzzle picture
571: Tissue Regeneration Design Puzzle
Status: Closed


Name: 571: Tissue Regeneration Design Puzzle
Status: Closed
Created: 06/06/2012
Points: 100
Expired: 06/15/2012 - 15:00
Difficulty: Beginner
Description: We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. Read the new blogpost for more details.
Categories: Design, Overall

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Joined: 08/30/2011

puzzle is open on the design overview page but the status is unreleased.
are you working on it right now to bring it up?

beta_helix's picture
User offline. Last seen 4 days 11 hours ago. Offline
Joined: 05/09/2008
Groups: None
Yes, unreleased means it'll be up soon :-)

We're just making sure it's working properly and the descriptions are helpful.

Joined: 12/06/2008
Groups: Contenders
Scoring artifacts

I'm not sure if any of the other top scorers on this puzzle are seeing this, but I am finding that saturating this helix with aromatics is producing the highest scores.

I doubt highly that a real-life helix could contain so many tryptophans, tyrosines, and phenylalanines, yet remain a stable structure.

We've seen this scoring bug, before.

marie_s's picture
User offline. Last seen 2 years 5 weeks ago. Offline
Joined: 05/18/2008
Groups: None
I aggree

I cannot get rid of 3 tryptophans

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