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568 (<150): Beginner CASP10 Refinement Puzzle: TR644
Status: Closed

Summary

Name: 568 (<150): Beginner CASP10 Refinement Puzzle: TR644
Status: Closed
Created: 06/03/2012
Points: 100
Expired: 06/10/2012 - 19:00
Difficulty: Beginner
Description: This is the first CASP10 Refinement Target. This model was the best server prediction for target T0644, generated by the SAM-T08 server. We've been told that ~85% of this model matches the native, so you just need to find which 15% to refine! More info in the puzzle comments. For players with fewer than 150 global points.
Categories: Beginner

Top Groups

RankGroupScorePoints
1NessunDorma11,630100
2foldeRNA11,38162
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4EasternBlotter11,16921
5Minions of TWIS11,15912

Top Soloists

RankPlayerGroupScorePoints
1gitwut 78 1421  11,661100
2Vincero 71 270 11,63096
3heebus 78 1421  11,62992
4jal3 78 1421  11,56687
5concoxide 78 1421  11,53783


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Comments

beta_helix's picture
User offline. Last seen 1 day 12 hours ago. Offline
Joined: 05/09/2008
Groups: None
START HERE:

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

____________________________________________________________________________

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=90&view=refinement

This was the page for the previous Foldit puzzles for this protein:
http://fold.it/portal/node/992552#comment-17172
and:
http://fold.it/portal/node/992650#comment-17486

You'll notice that indeed that previous puzzle had a register shift (assuming this starting model is correct in that region).

Note that the organizers give us this as a hint:

"Starting model's GDT_TS=85. Residues 1-25 are absent from the experimental structure and deleted from the model."

So, unfortunately the first 25 residues have been deleted (and we'll never know where that helix goes, it was probably a transmembrane anchor.) Therefore residue #1 on this puzzle corresponds to residue #26 on the previous versions.

GDT_TS=85 essentially means that 85% of the model superimposes correctly onto the native structure:
http://en.wikipedia.org/wiki/Global_distance_test

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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