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568 (<15): Beginner CASP10 Refinement Puzzle: TR644
Status: Closed

Summary

Name: 568 (<15): Beginner CASP10 Refinement Puzzle: TR644
Status: Closed
Created: 06/02/2012
Points: 100
Expired: 06/10/2012 - 19:00
Difficulty: Beginner
Description: This is the first CASP10 Refinement Target. This model was the best server prediction for target T0644, generated by the SAM-T08 server. We've been told that ~85% of this model matches the native, so you just need to find which 15% to refine! More info in the puzzle comments. For players with fewer than 15 global points.
Categories: Beginner

Top Groups

RankGroupScorePoints
17Monkeys11,2110
2L'Alliance Francophone11,0410
3Go Science10,6840
4Team China10,6310
5SETI.Germany8,7780

Top Soloists

RankPlayerGroupScorePoints
1heebus 98 2294  11,665100
2jal3 98 2294  11,46896
3boiled 98 2294  11,38794
4hansvandenhof 98 209  11,31592
5Nighty 98 2294  11,29490


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Comments

beta_helix's picture
User offline. Last seen 1 day 20 hours ago. Offline
Joined: 05/09/2008
Groups: None
START HERE:

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

____________________________________________________________________________

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=90&view=refinement

This was the page for the previous Foldit puzzles for this protein:
http://fold.it/portal/node/992552#comment-17172
and:
http://fold.it/portal/node/992650#comment-17486

You'll notice that indeed that previous puzzle had a register shift (assuming this starting model is correct in that region).

Note that the organizers give us this as a hint:

"Starting model's GDT_TS=85. Residues 1-25 are absent from the experimental structure and deleted from the model."

So, unfortunately the first 25 residues have been deleted (and we'll never know where that helix goes, it was probably a transmembrane anchor.) Therefore residue #1 on this puzzle corresponds to residue #26 on the previous versions.

GDT_TS=85 essentially means that 85% of the model superimposes correctly onto the native structure:
http://en.wikipedia.org/wiki/Global_distance_test

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