puzzle picture
566: CASP10 Target T0691
Status: Closed

Groups

RankGroupScorePoints
1Contenders11,783100
2Another Hour Another Point11,67077
3Void Crushers11,62759
4Anthropic Dreams11,60744
5L'Alliance Francophone11,56133
6Go Science11,48924
7foldeRNA11,38918
8Team Hungary11,21413
9Gargleblasters11,0519
10Russian team11,0276
11FoldIt@Netherlands10,8134
12Slovak National Team10,7163
13SETI.Germany10,6722
14Freedom Folders10,2942
157Monkeys10,1691
16Newton's Cradle10,1191
17Piratenpartei Deutschland9,9271
18Atlanta9,8671
19putting the eat in meat9,7191
20NessunDorma9,4621
21E?????! Heureka!8,9801
22Geekdo8,6251
23Mojo Risin'8,5421
24Biology-4th7,6771
25BOINC@Poland7,5541


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Comments

beta_helix's picture
User offline. Last seen 14 hours 2 min ago. Offline
Joined: 05/09/2008
Groups: None
Additional info about this CASP target

Here is the CASP link for this target (showing the amino acid sequence):
http://predictioncenter.org/casp10/target.cgi?id=92
____________________________________________________

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Leucines at residues 10, 14 & 15 are highly predicted to be in a helix. However, the Leucines at residues 62, 115, 125 & 127 are predicted to be sheets.
____________________________________________________

Link to template PDBs:

http://www.pdb.org/pdb/explore/explore.do?structureId=1gt1
http://www.pdb.org/pdb/explore/explore.do?structureId=1ew3
http://www.pdb.org/pdb/explore/explore.do?structureId=1pm1
http://www.pdb.org/pdb/explore/explore.do?structureId=1gm6
http://www.pdb.org/pdb/explore/explore.do?structureId=3qzk

beta_helix's picture
User offline. Last seen 14 hours 2 min ago. Offline
Joined: 05/09/2008
Groups: None
The first 18 residues are predicted to be in a helix

The N-terminal region of this CASP10 target is unaligned to any of the 5 templates we have given you, but it is predicted to be helical.

Here is a hint to easily make a helix (if that is what you want to attempt):

The rebuild tool takes structure assignment into account, so you can set the secondary structure to helix and then Rebuild. Foldit will then make a helix out of that region.

mimi's picture
User offline. Last seen 2 years 10 weeks ago. Offline
Joined: 11/17/2008
Groups: Contenders
is there a problem?

puzzle isn't actually appearing as an option on the list

beta_helix's picture
User offline. Last seen 14 hours 2 min ago. Offline
Joined: 05/09/2008
Groups: None
Sorry, was waiting on the update to devprev:

It should be up now, we were waiting on the update to devprev:
http://fold.it/portal/node/992806

specifically this bugfix:
Alignment Tool -
* Secondary structures are now assigned when threading

since this will make it easier when threading the template for this CASP10 target, due to the beta barrel topology: http://en.wikipedia.org/wiki/Beta_barrel

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