I'm a new foldit player and I was looking at some tutorials and such. I noticed most of the tutorials have things to do with going into structure mode and changing things. This makes me wonder, does that change the protein's chemical makeup? And if it does, then don't structure changes make the puzzle completely useless when trying to find the correct folded structure?
Another question I have is about the CASP puzzles. We aren't supposed to be changing things in the alignment, are we?