puzzle picture
560: Quick CASP10 T0660 Puzzle
Status: Closed

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3Go Science10,91153
4Void Crushers10,90138
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6foldeRNA10,77418
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16Mojo Risin'10,0821
17The Knights Who Say Ni!9,5251
18Geekdo9,3841
19xkcd9,3811
20Atlanta9,1631
21Structuralists9,1551
22Team Commonwealth9,0421
23Team Canada8,6511
24Russian team8,6511


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Comments

beta_helix's picture
User offline. Last seen 13 hours 35 min ago. Offline
Joined: 05/09/2008
Groups: None
Here is a screenshot of 15 different server models for T0660:

Below is a screenshot of all the Baker-RosettaServer, Quark, and Zhang-Server predictions.

The last 50 residues are shown as lines so that you can see how conserved the rest of the protein is.

The key to this CASP10 target will be figuring out where the last 50 residues go, so good luck!

And here is the link to secondary structure predictions for this target:
http://fold.it/portal/node/992632#comment-17334
____________________________

You might be able to tell from the above screenshot that all the servers have tried to form a helix (or 2 helices) with the last 50 residues.

Here is a hint to easily make a helix (if that is what you want to attempt):

The rebuild tool takes structure assignment into account, so you can set the secondary structure to helix and then Rebuild. Foldit will then make a helix out of that region.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons