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554: Quest to the Native CASP ROLL Target R0007
Status: Closed

Summary

Name: 554: Quest to the Native CASP ROLL Target R0007
Status: Closed
Created: 05/08/2012
Points: 100
Expired: 05/14/2012 - 07:00
Difficulty: Intermediate
Description: We were hoping to post new CASP 10 puzzles, but so far, this week's targets are too big for Foldit. The native for CASP ROLL target R0007 was released, however, and one of the Zhang server models was a lot closer than the other 14 server models we gave you. We are giving you just that starting model and the native as a guide so you can see what changes needed to be made. This will be good practice for future CASP 10 puzzles that have no templates. This puzzle's deadline will be extended if we don't post two new CASP 10 targets this week.
Categories: Overall, Prediction

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beta_helix's picture
User offline. Last seen 1 day 3 hours ago. Offline
Joined: 05/09/2008
Groups: None
Native guide scores: 11715.543

For those of you interested in knowing the score of the guide, it is at 11715.543. It has been slightly relaxed/fused, but you might be able to improve on that score if you reach the native state.

Here is a link to the Native: http://www.rcsb.org/pdb/explore/explore.do?pdbId=4dkc
_______________________________________________________________
If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

HINT: If you are having trouble with this puzzle, try using the "Align Guide" tool:

By right clicking on a region of the protein (not the guide) it will pull up a menu with 6 tools. The bottom right one is "Align Guide". Clicking on it will align the native guide to the region of the protein you selected.
This will help you see what sections on your protein correspond to the guide!

Working with the guide is much more user friendly when you use the advanced viewing options.
In the game click on Menu->General Options and select "Show Advanced GUI" and click Done.
Click on View, turn on 'Show Outline,' set the background color to white, and view stubs on the sidechains, view the guide, and set color relative to guide. Turn all the other view options off."

For even more info: http://foldit.wikia.com/wiki/Tlaloc%27s_Strategy#Technique_for_Matching_a_Guide

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons