Secondary structure tool
|Opened on:||Saturday, May 5, 2012 - 14:27|
|Last modified:||Tuesday, May 8, 2012 - 10:34|
It's too difficult to manually create secondary structures, especially helices. By this I mean creating the actual shape, not assigning the shape in structure mode. I'm told by better players that a helical structure can be created easily enough by banding the correct segments and using the rebuild tool, but that's tedious and I can rarely get it to work. We need a simple tool to automatically rebuild a portion of the protein into a specified secondary structure.
This would be similar to partial alignment, except that foldit would thread to an idealized secondary structure rather than to a real model protein. Basically we should be able to hit a button for "helix", enter a start and end segment, and have a helix created between those segments (probably creating a cut-point in the process.) Even for veteran players who are good at manual folding, I suspect this would be a time-saver, and for those of us who are not so experienced, it would be a huge help, especially in design puzzles. Difficulty in making the secondary structures I want is a major barrier to creativity; I often abandon an idea because I'm incapable of implementing it or because it would take forever to get what I want. If I could create the secondary structures instantly, I'd have much more time and energy for actual design.
I'd mostly use this tool for beta-helices, but if the capability were implemented, it would be nice to also have options like straight sheet, beta turn, or pi-helix.