puzzle picture
542: Advanced Alignment Cutpoint Puzzle
Status: Closed

Soloists

RankPlayerGroupScorePoints
226bluecrab 46 1380  8,6511
227darojas 46 1380  8,6121
228AlexSun 46 1380 Atlanta8,5721
229knickknack 46 1380  8,5581
230thealbatross 46 1380 Trinity8,5461
231Bearpaw 46 1380 Team Canada8,5451
232petrarovo 46 1380  8,5421
233paulsen 46 1380  8,5091
234armadillo314 46 1380  8,4991
235born2d 46 1380  8,4301
236spirogyra 46 1380  8,4171
237Mirilene 46 1380  8,4021
238EugeneTwo 46 1380  8,3951
239sbea3 46 1380  8,3921
240Alistair69 46 282  8,3921
241CoachB 46 1380  8,3811
242Cerzax 46 1380  8,3331
243harvardman 46 1380 Anthropic Dreams8,3301
244csid 46 1380  8,2861
245leafar-tb 46 1380  8,2861
246lachie 46 1380  8,2851
247Piotrus 46 1380  8,2781
248Core Commander 46 1380  8,2711
249mihic 46 1380  8,2201
250AndyDeathstar 46 1380  8,1771


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beta_helix's picture
User offline. Last seen 2 hours 39 min ago. Offline
Joined: 05/09/2008
Groups: None
Good practice for CASP 10

This puzzle is actually a CASP 9 target (T0552), which some of you might recognize from previous Foldit puzzles. (The results from previous puzzles finally led us to implementing the new cutpoints).

The native has been released, but it was solved using NMR and the ensemble of models has a lot of variation (as you can see below, this is WITH the termini trimmed):

NMR ensemble of 2L3B: First 10 models in NMR ensemble for 2L3BNMR ensemble of 2L3B: First 10 models in NMR ensemble for 2L3B

You can obviously examine the native all you want (and for fairness we are posting it here in the puzzle comments: http://www.rcsb.org/pdb/explore/explore.do?structureId=2l3b) but the goal of this puzzle is to help us all prepare for CASP 10, which starts in early May!

Clearly for CASP, there will be no natives, so we want to find out now if the current Alignment Tool is sufficient to perform well on the Template-Based targets.

WE KNOW THAT YOU WANT A SCISSOR TOOL TO PUT IN YOUR OWN CUTPOINTS :-) That will be added soon, but we want to make sure that the current cutpoint system does not have any major bugs.

Although you can just thread the starting alignment and massage/fold the protein to a decent conformation, we believe that initially moving the alignment around can result in a better starting model (making it easier to get close to the native). Obviously, this is what we want to find out... so please let us know!

Thank you and happy threading!

spmm's picture
User offline. Last seen 1 week 4 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
puzzle 369

would seem to be the earlier puzzle referred to in the text above. High scores there were 11062.xxx

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