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542: Advanced Alignment Cutpoint Puzzle
Status: Closed
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Soloists
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| 176 | NR22 45 1456 | | 9,277 | 2 | | 177 | lb494 45 1456 | | 9,264 | 1 | | 178 | Lollie 45 1456 | Richard Dawkins Foundation | 9,256 | 1 | | 179 | Tlaloc 45 1456 | Mojo Risin' | 9,243 | 1 | | 180 | DrMistry 45 1456 | | 9,227 | 1 | | 181 | Merf 45 73 | | 9,200 | 1 | | 182 | zuudoo 45 1456 | | 9,174 | 1 | | 183 | Squirrely 45 1456 | | 9,160 | 1 | | 184 | biomisha 45 1456 | | 9,124 | 1 | | 185 | phi16 9 28 | Anthropic Dreams | 9,114 | 1 | | 186 | blaydelk 45 1456 | | 9,108 | 1 | | 187 | krulon 45 1456 | foldeRNA | 9,108 | 1 | | 188 | Petrifolder 45 1456 | | 9,105 | 1 | | 189 | aSuAhSaD 45 1456 | | 9,104 | 1 | | 190 | c1261015 45 1456 | | 9,102 | 1 | | 191 | foldzapr 45 1456 | | 9,085 | 1 | | 192 | JCoviedo 45 1456 | | 9,067 | 1 | | 193 | d_lindenberger 45 1456 | | 9,047 | 1 | | 194 | momadoc 45 1456 | | 9,029 | 1 | | 195 | Lindata 45 1456 | | 9,019 | 1 | | 196 | cherry39 45 299 | | 9,009 | 1 | | 197 | scrambledegg 45 1456 | | 8,999 | 1 | | 198 | redguy 45 1456 | | 8,998 | 1 | | 199 | Alden_Adkins 45 1456 | | 8,996 | 1 | | 200 | Susanne 45 1456 | SETI.Germany | 8,993 | 1 | Need this puzzle? Log in to download.
Comments
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This puzzle is actually a CASP 9 target (T0552), which some of you might recognize from previous Foldit puzzles. (The results from previous puzzles finally led us to implementing the new cutpoints).
The native has been released, but it was solved using NMR and the ensemble of models has a lot of variation (as you can see below, this is WITH the termini trimmed):
You can obviously examine the native all you want (and for fairness we are posting it here in the puzzle comments: http://www.rcsb.org/pdb/explore/explore.do?structureId=2l3b) but the goal of this puzzle is to help us all prepare for CASP 10, which starts in early May!
Clearly for CASP, there will be no natives, so we want to find out now if the current Alignment Tool is sufficient to perform well on the Template-Based targets.
WE KNOW THAT YOU WANT A SCISSOR TOOL TO PUT IN YOUR OWN CUTPOINTS :-) That will be added soon, but we want to make sure that the current cutpoint system does not have any major bugs.
Although you can just thread the starting alignment and massage/fold the protein to a decent conformation, we believe that initially moving the alignment around can result in a better starting model (making it easier to get close to the native). Obviously, this is what we want to find out... so please let us know!
Thank you and happy threading!