puzzle picture
542: Advanced Alignment Cutpoint Puzzle
Status: Closed


151dbuske 46 426 9,4363
152Brewster 46 1603 Anthropic Dreams9,4363
153mitarcher 46 1603  9,4333
154ourtown 46 1603  9,4323
155Cfence 46 1603  9,4303
156FreeFolder 46 1603  9,4243
157demeter900 46 1603  9,4132
158klumpatsch 46 1603  9,4102
159tim311 46 1603  9,4102
160twisted1 46 1603  9,3992
161drjr 46 186 Anthropic Dreams9,3922
162aendgraend 46 1603 SETI.Germany9,3792
163anne romaine 46 1603  9,3692
164drumpeter18yrs9yrs 46 90  9,3692
165Bobnine 46 1603  9,3662
166jecauril 46 1603  9,3662
167martinf 46 949  9,3612
168keithv 46 1603 Anthropic Dreams9,3542
169Terciel 46 1603  9,3072
170Gettler 46 1603  9,3012
171mirjamvandelft 46 721  9,2962
172jdretired 46 1603  9,2892
173LavenderSky 46 1603  9,2882
174manu8170 46 81  9,2842
175Arne Heessels 46 158  9,2782

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beta_helix's picture
User offline. Last seen 3 hours 17 min ago. Offline
Joined: 05/09/2008
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Good practice for CASP 10

This puzzle is actually a CASP 9 target (T0552), which some of you might recognize from previous Foldit puzzles. (The results from previous puzzles finally led us to implementing the new cutpoints).

The native has been released, but it was solved using NMR and the ensemble of models has a lot of variation (as you can see below, this is WITH the termini trimmed):

NMR ensemble of 2L3B: First 10 models in NMR ensemble for 2L3BNMR ensemble of 2L3B: First 10 models in NMR ensemble for 2L3B

You can obviously examine the native all you want (and for fairness we are posting it here in the puzzle comments: http://www.rcsb.org/pdb/explore/explore.do?structureId=2l3b) but the goal of this puzzle is to help us all prepare for CASP 10, which starts in early May!

Clearly for CASP, there will be no natives, so we want to find out now if the current Alignment Tool is sufficient to perform well on the Template-Based targets.

WE KNOW THAT YOU WANT A SCISSOR TOOL TO PUT IN YOUR OWN CUTPOINTS :-) That will be added soon, but we want to make sure that the current cutpoint system does not have any major bugs.

Although you can just thread the starting alignment and massage/fold the protein to a decent conformation, we believe that initially moving the alignment around can result in a better starting model (making it easier to get close to the native). Obviously, this is what we want to find out... so please let us know!

Thank you and happy threading!

spmm's picture
User offline. Last seen 9 weeks 1 day ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
puzzle 369

would seem to be the earlier puzzle referred to in the text above. High scores there were 11062.xxx

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