puzzle picture
542: Advanced Alignment Cutpoint Puzzle
Status: Closed


251poiuytrewq 46 1293  8,1601
252Cosi 46 1293  8,1341
253Swiper 46 1293  8,1321
254Tump 46 1293  8,1281
255creinholt 46 1293  8,1121
256dart193 46 1293 8,0961
257jk408 46 1293  8,0691
258drising 46 1293  8,0671
259Chenakbar 46 1293  8,0671
260neutrinomania 46 1293  8,0501
261Acunil 46 1293  8,0311
262Shaneh2 46 1293 Ireland8,0251
263kleinesregenbog... 46 1293  8,0211
264plh 46 1293 Friday Lab8,0061
265Bautho 46 296 SETI.Germany7,9771
266costin 46 1293  7,9721
267Schnecke 46 1293  7,9691
268westrel3 46 1293 Anthropic Dreams7,9551
269keyejia 46 1293  7,9381
270Greg60 46 1293  7,9271
271Gerhk 46 1293  7,9261
272rafitxl22 46 1293  7,8901
273Savas 46 539 Eὕρηκα! Heureka!7,8741
274wenskye 46 1293 Anthropic Dreams7,8361
275BackBuffer 46 1293  7,8311

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beta_helix's picture
User offline. Last seen 13 hours 45 min ago. Offline
Joined: 05/09/2008
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Good practice for CASP 10

This puzzle is actually a CASP 9 target (T0552), which some of you might recognize from previous Foldit puzzles. (The results from previous puzzles finally led us to implementing the new cutpoints).

The native has been released, but it was solved using NMR and the ensemble of models has a lot of variation (as you can see below, this is WITH the termini trimmed):

NMR ensemble of 2L3B: First 10 models in NMR ensemble for 2L3BNMR ensemble of 2L3B: First 10 models in NMR ensemble for 2L3B

You can obviously examine the native all you want (and for fairness we are posting it here in the puzzle comments: http://www.rcsb.org/pdb/explore/explore.do?structureId=2l3b) but the goal of this puzzle is to help us all prepare for CASP 10, which starts in early May!

Clearly for CASP, there will be no natives, so we want to find out now if the current Alignment Tool is sufficient to perform well on the Template-Based targets.

WE KNOW THAT YOU WANT A SCISSOR TOOL TO PUT IN YOUR OWN CUTPOINTS :-) That will be added soon, but we want to make sure that the current cutpoint system does not have any major bugs.

Although you can just thread the starting alignment and massage/fold the protein to a decent conformation, we believe that initially moving the alignment around can result in a better starting model (making it easier to get close to the native). Obviously, this is what we want to find out... so please let us know!

Thank you and happy threading!

spmm's picture
User offline. Last seen 2 weeks 3 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
puzzle 369

would seem to be the earlier puzzle referred to in the text above. High scores there were 11062.xxx

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