puzzle picture
542: Advanced Alignment Cutpoint Puzzle
Status: Closed

Groups

RankGroupScorePoints
1Anthropic Dreams10,483100
2Void Crushers10,44581
3Contenders10,43064
4Go Science10,36251
5foldeRNA10,22340
6L'Alliance Francophone10,14731
7Another Hour Another Point10,09824
8Freedom Folders10,03218
9Nerdfighters10,02114
10FoldIt@Netherlands9,95010
11Androids9,9348
12Gargleblasters9,9306
13Team Hungary9,9104
14BOINC@Poland9,8833
15Richard Dawkins Foundation9,8492
16SETI.Germany9,8032
17Team Tornado9,7711
18Island Dreams9,7601
19Natural Abilities9,7331
20Wisconsin Pride9,4361
21Mojo Risin'9,2431
22Czech National Team8,8131
23Team China8,7831
24Atlanta8,5721
25Trinity8,5461


Need this puzzle? Log in to download.  

Comments

beta_helix's picture
User offline. Last seen 1 day 23 hours ago. Offline
Joined: 05/09/2008
Groups: None
Good practice for CASP 10

This puzzle is actually a CASP 9 target (T0552), which some of you might recognize from previous Foldit puzzles. (The results from previous puzzles finally led us to implementing the new cutpoints).

The native has been released, but it was solved using NMR and the ensemble of models has a lot of variation (as you can see below, this is WITH the termini trimmed):

NMR ensemble of 2L3B: First 10 models in NMR ensemble for 2L3BNMR ensemble of 2L3B: First 10 models in NMR ensemble for 2L3B

You can obviously examine the native all you want (and for fairness we are posting it here in the puzzle comments: http://www.rcsb.org/pdb/explore/explore.do?structureId=2l3b) but the goal of this puzzle is to help us all prepare for CASP 10, which starts in early May!

Clearly for CASP, there will be no natives, so we want to find out now if the current Alignment Tool is sufficient to perform well on the Template-Based targets.

WE KNOW THAT YOU WANT A SCISSOR TOOL TO PUT IN YOUR OWN CUTPOINTS :-) That will be added soon, but we want to make sure that the current cutpoint system does not have any major bugs.

Although you can just thread the starting alignment and massage/fold the protein to a decent conformation, we believe that initially moving the alignment around can result in a better starting model (making it easier to get close to the native). Obviously, this is what we want to find out... so please let us know!

Thank you and happy threading!

spmm's picture
User offline. Last seen 18 weeks 3 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
puzzle 369

would seem to be the earlier puzzle referred to in the text above. High scores there were 11062.xxx

User login
Download links:
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.12 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media


Search
Only search fold.it
Other Games: Mozak
Recommend Foldit
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons