puzzle picture
539: Beginner Immunotherapy Design Puzzle
Status: Closed

Summary

Name: 539: Beginner Immunotherapy Design Puzzle
Status: Closed
Created: 04/04/2012
Points: 100
Expired: 04/13/2012 - 23:59
Difficulty: Beginner
Description: We are giving you 3 linked residues and your job is try to design and fit them into a constrained region of the CTLA-4 protein. We know the general region in which we want you to place to residues, but we don't know exactly where is the best spot; look for good hydrophobic pockets or residues to make strong hydrogen bonds to. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle.
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Anthropic Dreams9,050100
2Go Science9,04981
3Team Tornado9,04964
4Void Crushers9,04951
5foldeRNA9,04840

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Comments

Joined: 06/17/2010
9026 pts start

It is my solution form gallery puzzle? Or this is some coincidence? ;]

Joined: 06/17/2010
BUG?

It is not a start point, I`m able to load my gallery solution...
Dev client automagically loaded my best state on start.
As far I remember it should be impossible?

beta_helix's picture
User offline. Last seen 4 days 1 hour ago. Offline
Joined: 05/09/2008
Groups: None
It looks like I was wrong and Gallery Solutions do get saved

Sorry for the confusion on this.

The great news is that already (after just 1 day) your Foldit solutions on this puzzle look really promising, we are very excited!!!

EvdH's picture
User offline. Last seen 7 years 17 weeks ago. Offline
Joined: 03/30/2012
Groups: None
The results so far look very

The results so far look very interesting, some of them are quite elegant! As a lot of you already discovered the pronounced cavity is a nice keyhole to use :). I hope the Easter weekend can give you even more inspiration. Keep up the good work!

Joined: 08/30/2011
general question

I have a general question which fit quite good in this puzzle. How do you chose the solutions you gonna work with? Simply best scoring? Diversity?
Diversity is a big thing in this puzzle, huh?
I have now a solution made offline which seem different, than my other solution AND it is still good scoring. Is it sufficient to work on it a bit more so that it is saved on the server. Do you save all the solutions generated or just the best scoring ones?

beta_helix's picture
User offline. Last seen 4 days 1 hour ago. Offline
Joined: 05/09/2008
Groups: None
We always save all your solutions generated on a given puzzle!

This translates to about 500,000 Foldit solutions per puzzle!

As you can imagine that is way too much to look at so we do filter a lot. The different filters depend on the puzzle type, but here are some general ones:

1) Examine the top-scoring soloist solutions for every player
2) Examine the top-scoring evolver solutions for every player
3) For design puzzles: Examine the top-scoring solutions for each unique sequence
4) Cluster the solutions and look at the most populated clusters (this can sometimes be a problem if one team produced many similar solutions) so sometimes we have to cluster in a different way:
5) Take the top-scoring solution and look for the next highest-scoring solution that has an RMSD of at least X Angstroms, and cluster that way down the list. This gives us many different high-scoring topologies to look at.

So for this particular puzzle, if you have two very different solutions that score well, we will examine both of them for sure (as long as they are structurally different from one another or have a different sequence).

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons