puzzle picture
532: Beginner Flu Puzzle
Status: Closed

Summary

Name: 532: Beginner Flu Puzzle
Status: Closed
Created: 03/19/2012
Points: 100
Expired: 03/28/2012 - 23:59
Difficulty: Beginner
Description: In this puzzle we are trying to determine the best locations to place two linked residues on the surface of Influenza H3 Hemagglutinin. We have given you distance constraints because we know the general region in which we want you to place to residues. However, we don't know exactly where is the best spot; look for good hydrophobic pockets or residues to make strong hydrogen bonds to. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle.
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1Contenders7,610100
2Go Science7,60883
3Anthropic Dreams7,60769
4foldeRNA7,60757
5Void Crushers7,60746
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Top Evolvers

RankPlayerGroupScorePoints
1Bletchley Park 28 32 Contenders7,610100
2CharlieFortsCon... 76 1437 Contenders7,60999
3mimi 76 1437 Contenders7,60897
4martinzblavy 76 1437 Contenders7,60895
5dembones 76 1437 Contenders7,60793
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Top Soloists

RankPlayerGroupScorePoints
1Bletchley Park 28 32 Contenders7,610100
2martinzblavy 76 1437 Contenders7,60999
3BootsMcGraw 76 1437 Contenders7,60997
4CharlieFortsCon... 76 1437 Contenders7,60995
5dembones 76 1437 Contenders7,60993
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Comments

Thu, 03/22/2012 - 12:46
#1
aditya_folds 76 1437
aditya_folds's picture
User offline. Last seen 7 years 20 weeks ago. Offline
Joined: 03/22/2012
Groups: None
folding

i need some sites to work with protein crystals data to solve for the coordinates

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Fri, 03/23/2012 - 06:11
#2
 beta_helix 76 1437
beta_helix's picture
User offline. Last seen 14 hours 9 min ago. Offline
Joined: 05/09/2008
Groups: None
Thanks for asking...

It might be best (at least for this puzzle) not to share your high scoring solutions outside your group.

Since there might not be THAT many different high-scoring configurations for this puzzle, it would be a pity to have all the top-scoring solutions be very similar across different Foldit teams.

You could always post your solutions after the puzzle closes to show others (they can still learn once the puzzle has ended).

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Mon, 03/26/2012 - 18:21
#3
alwen 21 91
alwen's picture
User offline. Last seen 2 weeks 3 days ago. Offline
Joined: 10/03/2011
Groups: Anthropic Dreams
Question on this one

I've been noticing in evo that the high scoring solutions seem to be mutated, and was just wondering if that is what you're looking for.

That is, are we looking for the best site for these two residues, or the best spot overall?

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Wed, 03/28/2012 - 14:17
#4
Rav3n_pl 76 1437
Rav3n_pl's picture
User offline. Last seen 20 weeks 2 days ago. Offline
Joined: 06/17/2010
Groups: Anthropic Dreams
All mutable

puzzles are to find best space/sidechain type confirmation.
If we can mutate - do it! :D

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Wed, 03/28/2012 - 17:57
#5
Aaron Chevalier 76 1437
Aaron Chevalier's picture
User offline. Last seen 7 years 9 weeks ago. Offline
Joined: 09/07/2011
Groups: None
That's right, we are trying

That's right, we are trying to find the best residue/position not just the best spot for the starting residue.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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