puzzle picture
Bonus Symmetry CASP ROLL R0007 Puzzle
Status: Closed

Summary

Name: Bonus Symmetry CASP ROLL R0007 Puzzle
Status: Closed
Created: 02/28/2012
Points: 20
Expired: 03/05/2012 - 23:59
Difficulty: Advanced
Description: The CASP ROLL organizers have told us that the native solved structure for R0007 forms "a noncovalent dimer". We are giving you the top 5 Foldit predictions from Puzzle 515, but you will be able to manipulate them as dimers using symmetry. You'll want to turn off all sidechains and visualizations, as this puzzle will likely crash many computers since this was already a large target. You should not spend too much time on this puzzle, it should really just be for fun. Therefore it will only be worth 20 global points.
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Top Groups

RankGroupScorePoints
1Contenders18,08720
2Go Science16,46217
3Anthropic Dreams16,45413
4Void Crushers16,40711
5CHNO Junkies16,3528

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1grabhorn 78 1584 Contenders18,08720
2HYLEE 78 1584 Go Science16,46220
3BitSpawn 78 1584 Anthropic Dreams16,44420
4marrslink 78 1584  16,41019
5johnmitch 78 6  16,40619


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Comments

beta_helix's picture
User offline. Last seen 5 days 1 hour ago. Offline
Joined: 05/09/2008
Groups: None
More info about this puzzle:

This is the information given by the CASP organizers:
http://predictioncenter.org/casprol/target.cgi?id=21&view=all

In CASP9 we had to skip these types of targets, because symmetry was not possible with Foldit... but that is no longer the case!

We wanted to give you the opportunity to fold R0007 in the context of a dimer, but we realize that this was already a big protein, and symmetry makes it even bigger.

This is why it is only worth 20 global points, think of it as an "extra credit" puzzle... it's just for fun so don't be too frustrated if it barely runs on your computer.

___Some possible hints___

I recommend turning off all sidechains, using Cartoon Thin, with Hydro Color and only showing Clashes. (If this is still too slow, you can try using "Line")

Since it forms a dimer, you probably want to look for a hydrophobic patch where the two sections come together. Coloring by Hydro can help you try to get as much orange at the interface.

If you have trouble loading this puzzle, try checking the box "disable network timeouts" when you login.

Unfortunately this CASP ROLL target is due on March 6th, so it needs to close late on the 5th.

Please have fun with this one!

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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