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503: CASP ROLL Puzzle 3c
Status: Closed

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beta_helix's picture
User offline. Last seen 1 day 8 hours ago. Offline
Joined: 05/09/2008
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Disulfides

Since this target has many Cysteines, we have enabled disulfide bonding for this puzzle. More info about Disulfide Bridges in Foldit here: http://foldit.wikia.com/wiki/Disulfide_Bridge. Once formed, you'll need to click "Show Bonds (sidechain)" to view them.
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You'll also notice that these server predictions did not form many disulfide bridges (and also that most of these predictions converged to very similar solutions). This may answer the comment from puzzle 499 about why disulfide bonding does not result in a big score gain:

http://fold.it/portal/node/991383#comment-14646

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons