puzzle picture
Beginner Puzzle (<150): T-cell Lymphoma
Status: Closed

Summary

Name: Beginner Puzzle (<150): T-cell Lymphoma
Status: Closed
Created: 01/10/2012
Points: 100
Expired: 02/11/2012 - 23:59
Difficulty: Beginner
Description: This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is very far from the correct native structure, can you use the Foldit tools you just learned to fix the model and match the guide? For help with Intro Puzzles, visit http://tinyurl.com/foldit-help . Make sure you have completed the Intro Puzzles (at least up to Level 4-5) before attempting these more difficult Science Puzzles. For players with fewer than 150 global points.
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beta_helix's picture
User offline. Last seen 1 day 10 hours ago. Offline
Joined: 05/09/2008
Groups: None
START HERE:

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

HINT: If you are having trouble with this puzzle, try using the "Align Guide" tool:

By right clicking on a region of the protein (not the guide) it will pull up a menu with 6 tools. The bottom right one is "Align Guide". Clicking on it will align the native guide to the region of the protein you selected.
This will help you see what sections on your protein correspond to the guide!

Working with the guide is much more user friendly when you use the advanced viewing options.
In the game click on Menu->General Options and select "Show Advanced GUI" and click Done.
Click on View, turn on 'Show Outline,' set the background color to white, and view stubs on the sidechains, view the guide, and set color relative to guide. Turn all the other view options off."

For even more info: http://foldit.wikia.com/wiki/Tlaloc%27s_Strategy#Technique_for_Matching_a_Guide

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons