puzzle picture
482: Advanced Alignment Puzzle
Status: Closed

Groups

RankGroupScorePoints
1Contenders10,749100
2Androids10,42383
3Anthropic Dreams10,33768
4L'Alliance Francophone10,33556
5Void Crushers10,27245
6Russian team10,24537
7foldeRNA10,15229
8Trailer Trash10,08824
9FoldIt@Netherlands10,08219
10Go Science10,05415
11Team Tornado9,92412
12E?????! Heureka!9,8569
13Foldit UK9,8037
14SETI.Germany9,7175
15chillerdown9,6324
16Natural Abilities9,5743
17SciFurs9,4442
18Valencia9,4222
19Extraterrestrials9,3331
20BOINC.Italy9,2681
21Worldthink.pl9,2401
22BOINC@Poland9,1951
23Team Toombs9,1861
24Team Hungary9,1271
25Crunching Family9,0861


Need this puzzle? Log in to download.  

Comments

beta_helix's picture
User offline. Last seen 7 hours 33 min ago. Offline
Joined: 05/09/2008
Groups: None
Starting Alignment is incorrect

We know the starting alignment is wrong, you might even have trouble threading it at all:

In the above screenshot, Foldit cannot resolve the gap between the red R and the D, therefore the alignment needs to be moved around so that Foldit is able to thread the sequence onto the template.

Junker's picture
User offline. Last seen 8 years 9 weeks ago. Offline
Joined: 09/22/2011
Groups: None
Do we have a server structure

Do we have a server structure prediction for this one ?

beta_helix's picture
User offline. Last seen 7 hours 33 min ago. Offline
Joined: 05/09/2008
Groups: None
we can post this puzzle using server predictions later

If you feel that would be useful, we can post server predictions for this one.
The best servers will most likely use this exact template, so we're hoping the Alignment Tool can get the job done.
I'll get server predictions ready for this one so we can repost the puzzle if needed.

Junker's picture
User offline. Last seen 8 years 9 weeks ago. Offline
Joined: 09/22/2011
Groups: None
My bad

What I actually meant was SAM prediction, I should have been more specific.

beta_helix's picture
User offline. Last seen 7 hours 33 min ago. Offline
Joined: 05/09/2008
Groups: None
ah... no problem!

We'll repost this one as a quick puzzle with the secondary structure predictions from the SAM server.

Junker's picture
User offline. Last seen 8 years 9 weeks ago. Offline
Joined: 09/22/2011
Groups: None
Thank You

I find those very helpful whenever the puzzle is not a very close match, or when the shape is not well defined. I would actually like to request that we get them with all of the CASP puzzles this time around as well, since many times it is helpful to have a rough guide of where to explore variations in the protein. Especially when combined with server predictions or similar proteins to thread from, they really help to visualize where changes may need to be made to improve a structure.

spmm's picture
User offline. Last seen 3 weeks 5 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
tutorials or video from this?

It would help the newer players who were not around when the alignment tool was implemented for this puzzle alignment solution and subsequent state to be shown as a video. The current tutorial is very basic.
I can do 7 layer phylo sequences easily but the connection between clicking on the actual puzzle and the letter alignment I find quite baffling. And yes I have read the instructions and watched the existing video. thanks

beta_helix's picture
User offline. Last seen 7 hours 33 min ago. Offline
Joined: 05/09/2008
Groups: None
good idea spmm

We should definitely make a tutorial video using this example since the initial alignment is clearly wrong.
Once this puzzle is closed (and some of you have been able to correctly move the alignment around) remind me (feel free to PM me about this) to make a video of those correct moves.

Thanks for the great suggestion!

Joined: 09/19/2011
Groups: Beta Folders
More info can be found on the comments section of the wiki

The Contenders did a great job with this puzzle and infjamc gave me permission to repost a response from him to me. It is very informative and can be found at the following link:

http://foldit.wikia.com/wiki/Puzzle_482

User login
Download links:
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.12 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media


Search
Only search fold.it
Other Games: Mozak
Recommend Foldit
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons