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460: Quest to the SOLVED Monkey Virus Protein
Status: Closed


Name: 460: Quest to the SOLVED Monkey Virus Protein
Status: Closed
Created: 09/22/2011
Points: 100
Expired: 10/03/2011 - 23:00
Difficulty: Intermediate
Description: The crystal structure of monomeric M-PMV retroviral protease, which causes AIDS in rhesus monkeys, has finally been released. You may have read about this protein in the news recently... so we thought we should post it again as a Quest to the Native. Once again we are giving you the 10 NMR models to work on, they are also in the Alignment Tool. After threading, make sure to press G to Align the Guide. We're sure you can get even closer to the native this time, and in less than 10 days!
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beta_helix's picture
User offline. Last seen 33 min 7 sec ago. Offline
Joined: 05/09/2008
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This was the famous Unsolved Monkey Virus Protein

This is the Quest to the Native version of Puzzle 390:

Now that the protein has been solved (thanks to all of you), the PDB has posted the solution:

For hints on how to use Partial Threading with the Alignment Tool, check out: http://fold.it/portal/node/989012#comment-9780

And if you weren't playing Foldit last December and want to see if you would have been able to get close to the native, you can always turn off the guide by press Shift-S.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons