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Beginner Puzzle: Copper Ion Binding Protein
Status: Closed

Summary

Name: Beginner Puzzle: Copper Ion Binding Protein
Status: Closed
Created: 08/23/2011
Points: 50
Expired: 09/30/2011 - 23:00
Difficulty: Beginner
Description: This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is trapped in a wrong conformation, can you use the Foldit tools you just learned to improve the model and match the guide? This version of the puzzle is only worth global 50 points.
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Comments

beta_helix's picture
User offline. Last seen 1 day 1 hour ago. Offline
Joined: 05/09/2008
Groups: None
START HERE:

if you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

HINT: If you are having trouble with this puzzle, try using the "Align Guide" tool:

By right clicking on a region of the protein (not the guide) it will pull up a menu with 6 tools. The bottom right one is "Align Guide". Clicking on it will align the native guide to the region of the protein you selected.
This will help you see what sections on your protein correspond to the guide!

Working with the guide is much more user friendly when you use the advanced viewing options.
In the game click on Menu->General Options and select "Show Advanced GUI" and click Done.
Click on View, turn on 'Show Outline,' set the background color to white, and view stubs on the sidechains, view the guide, and set color relative to guide. Turn all the other view options off."

For even more info: http://foldit.wikia.com/wiki/Tlaloc%27s_Strategy#Technique_for_Matching_a_Guide

gramps's picture
User offline. Last seen 4 years 43 weeks ago. Offline
Joined: 12/16/2010
what's the target for banding to the guide?

I've been burying the sphere at the end of a default band completely as possible into the guide shadow completely covering the base of the sidechain shadow you get when you mouse over the sidechain or stub; however, ...

in group chat one of my colleagues recommends lining up with the "collar" at the base of the sphere. Now that they've pointed this out I suspect the collar is actually a cone with point at the center of the sphere (mostly hidden by the sphere usually), and this point indicates the end of the band, but I recall no documentation on this.

So what's the scoop on what the parts of a band mean, and how we should band to a guide?

Joined: 09/29/2011
Groups: None
where's the puzzle?

i just worked a 13hr shift and then went to class and heard about this but cant find the puzzles? f it i'll try later when i'm not so tired.

beta_helix's picture
User offline. Last seen 1 day 1 hour ago. Offline
Joined: 05/09/2008
Groups: None
START HERE:

if you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

Get Started: Download
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons