The Electron Density Guide: how useful is it, and how can we make it more useful?

Case number:699969-990129
Topic:General
Opened by:jflat06
Status:Open
Type:Question
Opened on:Thursday, August 4, 2011 - 00:07
Last modified:Saturday, August 6, 2011 - 17:38

We recently ran the first Electron Density Puzzle, and from my limited talk with players over IRC after the puzzle closed, it seemed that many people ended up ignoring the guide at some point during the puzzle.

We would love feedback on how useful you individually found the guide. If you ended up ignoring it, why did you ignore it? What could be changed about it to make it more useful?

Thanks!

(Thu, 08/04/2011 - 00:07  |  4 comments)


Joined: 06/17/2010

Great thing would be "bond" somehow part of guide to certain segments/sidechains.
That way we can align guide to parts that we "see" are in good place.
I ignored guide because I cant rotate/move it to "right" position and "align" button just making more mess.

spmm's picture
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Joined: 08/05/2010
Groups: Void Crushers

I really liked the electron density and manually realigned it a several times doing early work on the loops, then used the button to get it tight - eventually didn't bother to realign manually but would have liked to have seen how close it was at the finish.

Also the 'align protein to map' is very slow and must really tax the compute, my laptop fan was going crazy and you would probably think twice before using on slower computers or having anything else running at the same time :-).

keypad5's picture
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Joined: 11/09/2009

I used the guide for a bit, but I ended up turning it off because I wasn't sure what I was doing with it. Perhaps if I stuck at it a bit more I might have got a better sense of how the guide and protein were interacting. I'm not sure.

gramps's picture
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Joined: 12/16/2010

The first instance of "Mr. ED" was fairly instructive and points to the importance of taking the Quest To The Native (QTTN) puzzle guides somewhat seriously as practice opportunities. Still not obvious just what to do with a complete or partial band set, as just yanking furiously on the whole set is usually counterproductive and breaks the model. I'm looking forward to future versions of this sort of challenge.

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