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443: Mini Arabidopsis Multi-Start Puzzle
Status: Closed

Summary

Name: 443: Mini Arabidopsis Multi-Start Puzzle
Status: Closed
Created: 07/27/2011
Points: 100
Expired: 08/06/2011 - 09:00
Difficulty: Intermediate
Description: This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 Zhang server models as starts for this puzzle. Each time you reset the puzzle one of them will randomly be chosen. They are also in the Alignment Tool so you can use partial threading and an extended chain. More info in the puzzle comments.
Categories: Overall, Prediction

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Comments

beta_helix's picture
User offline. Last seen 11 hours 6 min ago. Offline
Joined: 05/09/2008
Groups: None
More info about the unsolved structure of this protein:

In the long term, it has potential applications in controlling the amount of oil, protein, and/or starch that is stored in seeds. The mechanism by which it regulates composition is not understood.

Solving this structure would not only help guide our experimentation to test its structure, but also help us in understanding its potential regulatory partners, and ultimately in understanding how carbon flux in plants is controlled.

More info about how this protein negatively controls the bio-synthesis of starch in plants and regulates leaf and seed composition:
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-313X.2009.03793.x/full

beta_helix's picture
User offline. Last seen 11 hours 6 min ago. Offline
Joined: 05/09/2008
Groups: None
additional information on partial threading here ...
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons