puzzle picture
441: De-novo Freestyle 10
Status: Closed

Summary

Name: 441: De-novo Freestyle 10
Status: Closed
Created: 07/22/2011
Points: 100
Expired: 07/31/2011 - 17:00
Difficulty: Advanced
Description: We are giving you this currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are posted in the puzzle comments, but we have included them in the starting structure as well.
Categories: Overall, Prediction

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Comments

beta_helix's picture
User offline. Last seen 1 hour 22 min ago. Offline
Joined: 05/09/2008
Groups: None
Please try to use these secondary structure predictions:

These secondary structure predictions have been pre-loaded into this freestyle puzzle.

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the amino acid Leucine at residue 59 is highly predicted to be part of a helix. However, the Valine at residue 80 is highly predicted to be in a sheet or loop region (but not a helix).

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons