A future without global wiggle

Case number:699969-990039
Topic:General
Opened by:Seagat2011
Status:Closed
Type:Suggestion
Opened on:Friday, July 22, 2011 - 17:16
Last modified:Wednesday, August 27, 2014 - 02:51

If rebuilds are not random, and in fact are pulled from a datatbase, then we need to derive an equation, perhaps like one I mentioned earlier, that can normalize or even avergae (the score) of rebuilds having similar shapes, as a way to optimize out wiggle backbone and global wiggle. This will make work on puzzles even faster.

(Fri, 07/22/2011 - 17:16  |  3 comments)


infjamc's picture
User offline. Last seen 3 days 15 hours ago. Offline
Joined: 02/20/2009
Groups: Contenders

Interesting idea, but you might want to know that the two tools are different from a technical standpoint:

* Global wiggling are gradient-based optimization;
* While rebuilds are fragment insertions from known structures.

Hence, applying the strategy used for rebuilds for wiggling might actually be even LESS effective.

Joined: 08/24/2010

ah, so there really is no benefit to merging them, because there is no way for the fragment insertion to undergo a hidden markov-based analysis based on the codons.

Joined: 12/06/2008
Groups: Contenders
Status: Open » Closed

Sounds like the question was answered.

Closing feedback.

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