puzzle picture
413: De-novo Freestyle 6
Status: Closed


Name: 413: De-novo Freestyle 6
Status: Closed
Created: 04/23/2011
Points: 100
Expired: 05/03/2011 - 23:00
Difficulty: Advanced
Description: We are giving it to you this currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are posted in the puzzle comments, but we have included them in the starting structure as well. Since this protein chain is quite long, we are giving you 3 extra days to work on it.
Categories: Overall, Prediction

Top Groups

2Anthropic Dreams13,31380
4Go Science12,62450
5Void Crushers12,60939

Top Evolvers

Top Soloists

Need this puzzle? Log in to download.  


beta_helix's picture
User offline. Last seen 8 hours 17 min ago. Offline
Joined: 05/09/2008
Groups: None
Please try to use these secondary structure predictions:

As requested in the feedback, http://fold.it/portal/node/989298 these secondary structure predictions have been pre-loaded into this freestyle puzzle.

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the amino acid Leucine at residue 171 is highly predicted to be part of a helix. However, the Leucine at residue 154 is equally predicted to be a sheet or loop.

lynnai's picture
User offline. Last seen 1 year 12 weeks ago. Offline
Joined: 05/16/2008

Why can't I see this puzzle in the game client?

beta_helix's picture
User offline. Last seen 8 hours 17 min ago. Offline
Joined: 05/09/2008
Groups: None
it's up now!

Sorry for the delay!

User login
Download links:
  Windows    OSX    Linux  
(10.12 or later)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media

Only search fold.it
Other Games: Mozak
Recommend Foldit
Top New Users

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons