puzzle picture
412: Electron Density Trace Puzzle
Status: Closed

Summary

Name: 412: Electron Density Trace Puzzle
Status: Closed
Created: 04/16/2011
Points: 100
Expired: 04/23/2011 - 23:00
Difficulty: Intermediate
Description: This Rosetta model was generated by trying to fit an electron density map, but as you can see the resulting trace looks pretty bad. We have tried various Rosetta protocols on this model but they aren't able to make it look any better, so we are hoping your human skills can spot what areas need to be improved the most.
Categories: Overall, Prediction

Top Groups

RankGroupScorePoints
41Purdue BoilerFolders7,5761

Top Evolvers

RankPlayerGroupScorePoints
41Dyack 78 1437 Russian team10,80532
42apple.muncy 78 1437 10,39231
43Susanne 78 1437 SETI.Germany10,02730

Top Soloists

RankPlayerGroupScorePoints
41drjr 78 351 Anthropic Dreams11,18834
42Dane2010 78 1437 Anthropic Dreams11,16833
43mberna00 50 211  11,13932
44vertex 78 1437  11,12731
45heather-1 78 82  11,12330


Need this puzzle? Log in to download.  

Comments

Joined: 06/17/2010
Our goal is

to optimize it or make own folds?
Make totally fifferent aligement or "just" optimize existing one?

Joined: 02/23/2011
AA are probably where they should be?

I looked up Electron Density Trace and I got the impression that the method predicts where each AA probably is with some margin for error. So, does that mean we should try not to change their locations too much? Is there any chance you can show us the original results with the probabilities?

beta_helix's picture
User offline. Last seen 1 hour 48 min ago. Offline
Joined: 05/09/2008
Groups: None
thanks for asking!

Indeed, the data indicates that this model is close to the native geometrically but you can see that it needs a lot of work and optimization.

So drastic restructuring moves should not be necessary, but finding the native low-energy well should still be a challenge!

I will see if we can provide you with some of the experimental data, if not on this puzzle we can try it with future puzzles.

Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons