puzzle picture
412: Electron Density Trace Puzzle
Status: Closed

Soloists

RankPlayerGroupScorePoints
251Asian hedgehog 81 1768  7,4381
252Virion157 81 1768  7,4371
253kingjin 81 1768  7,4361
254x_n0na_x 81 1768  7,4361
255zonk1024 81 1768  7,4361
256behemod 81 1768  7,4351
257JhackOfAllTrades 81 1768  7,4351
258Sgt. Awesome 81 1768  7,4351
259Calipedro 81 1768  7,4351
260alphatauri 81 1768  7,4341
261fractalman 81 1768  7,4291
262Steb 81 1768  7,4261
263Christoph 81 1768 7,4201
264maxwell_thethird 81 1768 Anthropic Dreams7,4201
265gueberschwihr 81 1768  7,4201
266oberburgermeister 81 1768  7,4201
267supofolder 81 1768  7,4201
268Ashokan 81 1768  7,4201
269Asymptote 81 1768  7,4201
270Spherhorse 81 1768  7,4201
271YOUBET3 81 1768  7,4201
272Phaiix 81 1768  7,4201
273Prof Void 81 1768  7,4201
274aaronhanpark 81 1768  7,4201
275pyro670 81 1768  7,4201


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Comments

Joined: 06/17/2010
Our goal is

to optimize it or make own folds?
Make totally fifferent aligement or "just" optimize existing one?

Joined: 02/23/2011
AA are probably where they should be?

I looked up Electron Density Trace and I got the impression that the method predicts where each AA probably is with some margin for error. So, does that mean we should try not to change their locations too much? Is there any chance you can show us the original results with the probabilities?

beta_helix's picture
User offline. Last seen 6 days 16 hours ago. Offline
Joined: 05/09/2008
Groups: None
thanks for asking!

Indeed, the data indicates that this model is close to the native geometrically but you can see that it needs a lot of work and optimization.

So drastic restructuring moves should not be necessary, but finding the native low-energy well should still be a challenge!

I will see if we can provide you with some of the experimental data, if not on this puzzle we can try it with future puzzles.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons