puzzle picture
406: Freestyle Nitric Oxide Puzzle
Status: Closed

Summary

Name: 406: Freestyle Nitric Oxide Puzzle
Status: Closed
Created: 03/22/2011
Points: 100
Expired: 03/28/2011 - 23:00
Difficulty: Advanced
Description: ***SEQUENCE LOGO NOW POSTED IN PUZZLE COMMENTS*** There will be more puzzles about this currently unsolved protein, but we wanted to start you off with it as an extended chain. Use all your skills to fold it up as best as you can. We will post a blog with details about this protein soon!
Categories: Overall, Prediction

Top Groups

RankGroupScorePoints
1Anthropic Dreams12,155100
2Contenders12,11176
3foldeRNA12,09656
4Pauling's Pitbulls11,99841
5Void Crushers11,77530

Top Evolvers

Top Soloists

RankPlayerGroupScorePoints
1keypad5 80 1853 Anthropic Dreams12,118100
2Mark- 80 1853 Contenders12,08398
3aap 80 1853  12,08395
4groovermctuber 80 1853 Pauling's Pitbulls11,99893
5gurch 80 344  11,84391


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Comments

beta_helix's picture
User offline. Last seen 2 days 5 hours ago. Offline
Joined: 05/09/2008
Groups: None
secondary structure predictions
The SAM T08 server seems to be down, so we used some basic secondary structure predictions (which are the ones shown in the puzzle) We'll post a sequence logo when the SAM server comes back up!
beta_helix's picture
User offline. Last seen 2 days 5 hours ago. Offline
Joined: 05/09/2008
Groups: None
sequence logo

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the amino acid Isoleucine at residue 25 is highly predicted to be part of a helix. However, the Leucine at residue 133 is predicted to be part of a beta sheet.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons