infjamc's picture
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Joined: 02/20/2009
Groups: Contenders
Does this structure feature a chain break again?

The backbone of residues #11-12 look strange...

beta_helix's picture
User offline. Last seen 6 days 12 hours ago. Offline
Joined: 05/09/2008
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yes

There is indeed a chain break between Lysine 11 and Threonine 12, six residues are missing in the native structure (PDB code: 3KZD).

We could have just ignored the terminal strand (and trimmed the first 11 residues) but it seems important to the stability of the protein.

We could also just add the missing residues back in and let you guess where they should go, but since this is a beginner puzzle we didn't want to confuse new Foldit players (since it wouldn't match the guide).

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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