puzzle picture
Beginner Puzzle: T-cell Lymphoma Invasion Protein
Status: Closed

Groups

RankGroupScorePoints
1Void Crushers10,351100
2Contenders10,33981
3Anthropic Dreams10,33565
4foldeRNA10,28852
5Go Science10,25341
6Ninjas10,22432
7Natural Abilities10,21925
8Free-DC10,21019
9Russian team10,17615
10Pauling's Pitbulls10,13211
11xkcd10,0098
12L'Alliance Francophone9,9926
13Team Tornado9,9665
14Slovak National Team9,9344
15SETI.Germany9,9123
16Another Hour Another Point9,8352
17Mojo Risin'9,7861
18Penny-Arcade9,7831
19hhv99,7551
20Nerdfighters9,7131
21Ukraine9,6781
22Team Commonwealth9,6381
23TT-group9,6291
24Czech National Team9,6041
25E?????! Heureka!9,5371


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Comments

infjamc's picture
User offline. Last seen 2 years 37 weeks ago. Offline
Joined: 02/20/2009
Groups: Contenders
Does this structure feature a chain break again?

The backbone of residues #11-12 look strange...

beta_helix's picture
User offline. Last seen 3 hours 6 min ago. Offline
Joined: 05/09/2008
Groups: None
yes

There is indeed a chain break between Lysine 11 and Threonine 12, six residues are missing in the native structure (PDB code: 3KZD).

We could have just ignored the terminal strand (and trimmed the first 11 residues) but it seems important to the stability of the protein.

We could also just add the missing residues back in and let you guess where they should go, but since this is a beginner puzzle we didn't want to confuse new Foldit players (since it wouldn't match the guide).

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons