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Beginner Puzzle: T-cell Lymphoma Invasion Protein
Status: Closed

Summary

Name: Beginner Puzzle: T-cell Lymphoma Invasion Protein
Status: Closed
Created: 03/20/2011
Points: 100
Expired: 04/20/2011 - 23:00
Difficulty: Intermediate
Description: This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is very far from the correct native structure, can you use the Foldit tools you just learned to fix the model and match the guide?
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Comments

infjamc's picture
User offline. Last seen 2 years 24 weeks ago. Offline
Joined: 02/20/2009
Groups: Contenders
Does this structure feature a chain break again?

The backbone of residues #11-12 look strange...

beta_helix's picture
User offline. Last seen 5 days 18 hours ago. Offline
Joined: 05/09/2008
Groups: None
yes

There is indeed a chain break between Lysine 11 and Threonine 12, six residues are missing in the native structure (PDB code: 3KZD).

We could have just ignored the terminal strand (and trimmed the first 11 residues) but it seems important to the stability of the protein.

We could also just add the missing residues back in and let you guess where they should go, but since this is a beginner puzzle we didn't want to confuse new Foldit players (since it wouldn't match the guide).

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons