puzzle picture
400: De-novo Freestyle 4
Status: Closed

Summary

Name: 400: De-novo Freestyle 4
Status: Closed
Created: 02/15/2011
Points: 100
Expired: 02/23/2011 - 23:00
Difficulty: Advanced
Description: Our 400th puzzle is another currently unsolved protein that we are giving to you as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are posted in the puzzle comments, you'll notice this sequence is similar to Puzzle 398: De-novo Freestyle 3. THIS PUZZLE HAS BEEN EXTENDED BY 1 DAY!
Categories: Overall, Prediction

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Comments

beta_helix's picture
User offline. Last seen 21 hours 41 min ago. Offline
Joined: 05/09/2008
Groups: None
Please try to use these secondary structure predictions:

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the amino acid Leucine at residue 26 is highly predicted to be part of a helix. However, the Leucine at residue 34 is predicted to have an equal probability of being anything.

beta_helix's picture
User offline. Last seen 21 hours 41 min ago. Offline
Joined: 05/09/2008
Groups: None
PUZZLE EXTENDED BY 1 FULL DAY

Due to the scheduled downtime on Tuesday:
http://fold.it/portal/node/989289

Joined: 05/14/2010
Groups: None
The protein is Bile acid

The protein is Bile acid 7a-dehydratase

It belongs to the bacteria organism Eubacterium sp.

Catalyzes the dehydratation of 7-alpha,12-alpha-dihydroxy-3-oxochol-4-enoate. The enzyme can also use 7-alpha-hydroxy-3-oxochol-4-enoate as a substrate but not 7-alpha,12-alpha-dihydroxy-3-oxochol-5-beta-anoate, 3-alpha,7-alpha,12-alpha-trihydroxychol-5-beta-anoate or 7-beta-hydroxy-3-oxochol-4-enoate

For more info: Go to the uniprot ascession number P19412

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons