puzzle picture
398: De-novo Freestyle 3
Status: Closed

Summary

Name: 398: De-novo Freestyle 3
Status: Closed
Created: 02/05/2011
Points: 100
Expired: 02/12/2011 - 23:00
Difficulty: Advanced
Description: This currently unsolved protein does not have any templates that we can use, so we are giving it to you as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are posted in the puzzle comments.
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Comments

beta_helix's picture
User offline. Last seen 5 days 23 hours ago. Offline
Joined: 05/09/2008
Groups: None
Please try to use these secondary structure predictions:

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the amino acid Leucine at residue 26 is highly predicted to be part of a helix. However, the Leucine at residue 34 is predicted to have an equal probability of being anything.

beta_helix's picture
User offline. Last seen 5 days 23 hours ago. Offline
Joined: 05/09/2008
Groups: None
looks like that's the one
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons