I was invited the University of Washington today and met with Zoran Popović, Firas Khatib (Beta_Helix), and David Baker. We discussed a number of things in the time I had there. One thing that came up with David Baker was about how to improve the information about foldit that is available. I told him that I'd at least try to form the list of questions that need answering.
This is a chance to improve much of the information available on the wiki. So here is your chance to ask questions about things related to the biology in foldit. You ask it, and we'll try to get some answers out of the foldit guys.
Just to give you an example of the kind of question I think we might get answered:
What does rebuild actually do? As I understand it, it looks at a database of segments from proteins with known native structures and tries to find segments that fit the sequence of amino acids and the endpoints of the rebuild. How exactly does that work? Where does that database come from? Who maintains it? Is it being added to as more natives are determined? Is it hardcoded into the program or downloaded from the server (i.e. can it change frequently or at all?)? Is this even the correct understanding?
Ask away, and we'll try to get the questions answered using words that a non-biologist, like me, can understand.